Golden Thread
Golden Thread
Learn More

We imagine a world where every child with cancer receives the best care, experiences the reality of a cure, and has the chance to thrive.

Our Mission

Each year, 15,000 American families hear the devastating words: “Your child has cancer.”

More than 1,600 children in the U.S. will die of cancer this year, making it the second leading cause of death in children. Around the world, only 37% of children diagnosed with cancer will survive beyond five years.

Pediatric cancer shatters lives—devastating families, communities, and futures. When a child is lost to cancer, we lose a life full of purpose and potential. Every life lost is a dream unrealized.

Thanks to advances in research and medicine, we have never been closer to changing this, but progress is not guaranteed.

Significant challenges still stand between today’s science and tomorrow’s cures.

Pediatric cancer is significantly underfunded, and existing funding models don’t always reach the areas with the greatest need or potential impact. With limited federal investment, much of the support comes from small, disease-focused nonprofits — organizations that do remarkable work but are not built to address broader, system-level challenges on their own.

Our mission is to remove the barriers that slow progress in pediatric cancer by connecting people, ideas, and resources to accelerate discovery and improve care for every child.

Golden Thread is a physician-led nonprofit that identifies problems and creates meaningful solutions.

About Us

As pediatric oncologists, we’ve stood beside families on the hardest days of their lives — and on some of the most hopeful.

We have witnessed the power of love, science, and sustained support. We have seen how a single connection — a doctor, a treatment, a breakthrough — can change everything.

As physicians and advocates we are serious about impact, honest about challenges, and deeply committed to the children and families we serve. 

We have spent countless hours caring for children with cancer. We have advocated for them from the bedside and worked hard to find them better cures. Those years have shown us where the system succeeds, and where it falls short.

We want our patients to have access to the best care and the expertise they need and deserve. We want research to be better and faster because we know that our patients don’t have time to wait.

We also know how much people want to make a difference. Once they learn about our work and our patients, they ask the same question: How can I help?

For a long time, we didn’t have a good answer.

So we created one.

We founded Golden Thread to give people a way to turn compassion into action, and action into progress.

How We Work

Advancement in medicine is not linear—progress in pediatric cancer requires strategic alignment across clinical care, research, policy, philanthropy, and industry. We see where research stalls, where access to expert care is limited, and where systems fail the children and families they are meant to serve.

Collaboration and partnership are key to our success. 

We partner with physicians and researchers to understand and identify the most impactful opportunities to accelerate discovery and improve treatment. We then build a strategic roadmap to address funding, policy and legislation, research, and partnerships. We work within our extensive network across these sectors - removing the barriers and making real progress.

We approach this work guided by our core values:

COLLABORATION
Uniting partners across medicine, science, philanthropy, and policy to solve problems no single institution or consortium can fix alone.

INNOVATION
Developing creative, innovative solutions to find new ways to address complex challenges in pediatric cancer.

IMPACT
Strategic focus and pragmatic workflows leading to tangible improvements in research and patient care.

EMPATHY
Listening, understanding, and compassion. A humanistic approach - people not cases.

Our Team

Ashley Margol, MD, MS
Founder, President
Cassie Kline, MD, MAS
Founder, Executive Director

Join our community of changemakers. You are the thread that connects it all.

How You can Help

This work is urgent. It is personal. 

It relies on connection – connection between science, resources, and people who act.

Together, we can turn connection into progress — and progress into cures.

Ways to get involved:

Partner with us: Bring your expertise, technology or resources

Collaborate on Innovation: Co-design and scaled new solutions

Invest in Progress: Support our initiatives

Join Us

Send us a quick note if out if you have an idea, want to be part of solution or want more information.

I am Joining the Thread

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Sign up to receive updates.

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Our Current Partners